Staging of Type 1 Diabetes


From ADA Standards of Care 2017 – Page S12

The rate of progression is dependent on the age at first detection of antibody, number of antibodies, antibody specificity, and antibody titer.
Glucose and A1C levels rise well before the clinical onset of diabetes, making diagnosis feasible well before the onset of DKA.
Three distinct stages of type 1 diabetes can be identified (Table 2.1) and serve as a framework for future research and regulatory decision making (4,5).