Medtronic ended 2025 with a bang, launching three new continuous glucose monitors (CGMs): Instinct, Simplera
Sync TM , and Simplera TM . These FDA-approved CGM options join the already established Medtronic Guardian TM 4 CGM.
Let’s explore the latest Medtronic CGM options to help you match the best CGM for your clients’ needs.
Medtronic CGM Lineup
All of Medtronic’s CGM options function without fingerstick calibrations, making glucose monitoring simpler. Each CGM connects to a specific Medtronic diabetes device to improve glycemic control. While CGM functionality is similar across the lineup, key differences can influence which option is the best fit for your clients.
The Guardian TM 4 was introduced in 2023 and is still available. This sensor requires rechargeable components. It also differs from the newer options in size and insertion
technique.
The Latest Medtronic CGM Options
Guardian TM 4
- Disposable sensor with rechargeable transmitter
- Requires the use of 2 hands to insert
- Up to 7-day wear time
- 2-hour warm-up period
- Approved for ages 7 years old and up
- Compatible with the MiniMed TM 780G system
- Size: 2.0 x 2.6 in
The Instinct, Simplera Sync TM, and Simplera TM are all-in-one, disposable models with no rechargeable components and can be inserted using just one hand. ¹ The smaller size of these options can be a significant factor for clients.
Instinct
- Disposable all-in-one sensor made by Abbot in partnership with Medtronic
- One-handed insertion
- 15-day wear time
- 1 hour warm-up period
- Approved for ages 7 years old and up
- Compatible with the MiniMed TM 780G system
- Compatible with InPen TM smart insulin pen in the MiniMed Go™ system (FDA-approved January 2026, with expected launch later in 2026) ²
- Size: 0.11 x 0.83 in
Simplera Sync TM
- Disposable all-in-one sensor
- One-handed insertion
- 6-day wear time with a 24-hour grace period
- 2-hour warm-up period
- Approved for ages 7 years old and up
- Compatible with the MiniMed TM 780G system
- Size: 0.19 x 1.13 in
Simplera TM
- Disposable all-in-one sensor
- One-handed insertion
- 6-day wear time with a 24-hour grace period
- 2-hour warm-up period
- Approved for ages 18 years old and up
- Compatible with the InPen TM smart insulin pen system
- Size: 0.19 x 1.13 in
Finding the Perfect Match
As diabetes healthcare providers, you are often asked to help navigate CGM choices. To best achieve this, you work with clients to explore their personal preferences, clinical needs, physical limitations, and comfort with technology to find the most appropriate option.
Who may benefit from the new CGM options?
Individuals who are:
- Looking for simpler technology
- Experiencing decreased hand dexterity
- Wanting a smaller, lower-profile sensor
- Preferring a longer wear time
- Seeking a disposable CGM option
As Medtronic CGMs continue to evolve, diabetes healthcare professionals support clients in choosing the option that best suits their needs. Your clinical insight, familiarity with each CGM, and assessment of the individual client’s goals and preferences help ensure that diabetes technology is used as an empowering tool rather than a barrier to care.
References:
- Medtronic. (n.d.). Medtronic continuous glucose monitors (CGM) comparison. https://www.medtronicdiabetes.com/customer-support/sensors-and-transmitters-support/compare-sensors
- Medtronic Diabetes. (2026, January 12). Medtronic Diabetes announces FDA clearance for MiniMed Go™ Smart MDI system featuring Instinct sensor made by Abbott. [Press Release]. https://news.medtronic.com/2026-01-12-Medtronic-Diabetes-announces-FDA-clearance-for-MiniMed-Go-TM-Smart-MDI-system-featuring-Instinct-sensor-made-by-Abbott
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