Question of Week | Best action before starting tirzepatide (Mounjaro)?

AR is 36 years old with type 2 diabetes and a BMI of over 40.  Current A1C 7.9%, UACR less than 30, and GFR more than 60.  Current diabetes medications include metformin, sitagliptin, and empagliflozin at maximum doses.  AR is prescribed the new dual incretin tirzepatide (Mounjaro) to help improve glucose levels and support weight loss. 

Before starting tirzepatide (Mounjaro), what action do you recommend to the provider?

  1. Repeat the UACR and GFR to verify kidney function.
  2. Stop the sitagliptin.
  3. Decrease metformin dose to prevent hypoglycemia.
  4. Evaluate thyroid function.

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New Injectable – “TwinCretin” on Printed PocketCards

We have just added this novel, first in class, dual incretin hormone therapy, Tirzepatide (Mounjaro), to our printed version of our Diabetes Medication PocketCard.

This new twin therapy includes not only a GLP-1 Receptor Agonist, but also a Glucose-dependent insulinotropic polypeptide (GIP), which magnifies the therapeutic effectiveness. The SURPASS studies indicate that study participants experienced an A1C drop of up to 2.5% and weight loss of up to 10kg or more.


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