New Rapid Bolus Insulin Approved

This newly FDA approved rapid-acting insulin analog is aimed at reducing post-meal glucose spikes.

Lyumjev also known as insulin lispro-aabc, is approved for adults with Type 1 or Type 2 diabetes, can be taken before meals or even 20 minutes into the meal.

Insulin lispro-aabc (Lyumjev) by Lilly is comparable to Fiasp by Novo Nordisk since they are both very rapid-acting insulins that are detectable in the circulation within minutes of injection.

Insulin lispro-aabc (Lyumjev) appears in circulation approximately 1 minute after injection, peaks at 57 minutes and has an effective duration of about four to five hours. The safety and effectiveness of pediatrics with diabetes has not been established.


Insulin lispro-aabc (Lyumjev) is produced by recombinant DNA technology using a non-pathogenic strain of E coli. Insulin lispro-aabc differs from human insulin due to a switching of lysine and proline in the B28 and B29 position. Its chemical name is Lys(B28), Pro(B29) human insulin analog. See the package insert for more information.

Lys(B28), Pro(B29) human insulin lispro-aabc

Insulin lispro-aabc (Lyumjev) will be offered at the same price as lispro (Humalog). Lilly will also offer Lyumjev at $35 per month for people who are uninsured or have commercial insurance through its Insulin Value Program. The $35 cap applies regardless of the number of insulin doses required.

How supplied:
Insulin lispro-aabc (Lyumjev) comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter) and a variety of delivery options, including the Junior KwikPen® which allows for 0.5 unit dosing increments.

Lyumjev Injection: 100 units/mL (U-100) available as:
• 10 mL multiple-dose vial
– 3 mL 300 unit KwikPen® (5 pens)
• 3 mL 300 unit Junior KwikPen® 0.5 unit dose increment (5 pens)
• 3 mL 300 unit Tempo Pen™ (5 pens)
• 3 mL 300 unit cartridges (5 cartridges)

Lyumjev Injection: 200 units/mL (U-200) available as:
• 3 mL KwikPen® (2 pens with 600 units each)

Discard opened or unopened insulin lispro-aabc (Lyumjev) vials, pens, and cartridges stored at room temperature below 86°F (30°C) after 28 days.

Stay tuned for more new insulin approvals and updates to our Insulin PocketCards!

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