For last week’s practice question, we quizzed participants on unpredictable glucose patters with bloating and nausea. 76% of respondents chose the best answer. We want to clarify and share this important information, so you can pass it on to people living with diabetes and your colleagues, plus prepare for exam success!
Before we start though, if you don’t want any spoilers and haven’t tried the question yet, you can answer it by clicking here.

CL is a 58-year-old individual with type 1 diabetes for 35 years. Their current therapy includes a CGM with an automated insulin delivery system, and they announce their meal 15-20 minutes before eating. Last HgbA1c is 7.4%, but they report recent worsening, unpredictable glucose patterns. CGM data review shows Time in Range is 62% with 4% below 70 mg/dL. Patterns note after breakfast, glucose drops from 110-130 mg/dL to 60-70 mg/dL within 1–2 hours, then rises to 220-280 mg/dL 3–4 hours later, and after dinner, glucose remains stable initially but rises to 240-280 mg/dL late in the evening. CL also reports an onset of bloating and occasional nausea.
What could be considered a potential contributor to this individual’s glucose variability?
- A. Inaccurate carbohydrate counting creating an increased variability in glucose patterns.
- B. Excess programmed basal insulin causing post-meal glucose fluctuations
- C. Delayed gastric emptying resulting in a mismatch between insulin action and glucose absorption. Consider a referral for a gastric emptying study.
- D. A high-carbohydrate and high-fat dietary pattern causing prolonged glucose elevations after meals.

Getting to the Best Answer
Answer A is incorrect. 4.93% chose this answer: “Inaccurate carbohydrate counting creating an increased variability in glucose patterns.” While carbohydrate counting errors can contribute to glucose variability, CL reports consistent meal announcement and insulin dosing before meals. The CGM pattern is also not typical of carbohydrate-counting challenges alone. A decline followed by a delayed rise several hours after eating suggests that the timing of glucose absorption may not align with insulin action.
Answer B is incorrect. 5.91% of you chose this answer, “Excess programmed basal insulin causing post-meal glucose fluctuations.” Excess basal insulin can contribute to hypoglycemia, but it typically causes a glucose decline independent of meals, and depending on the AID system, basal rate adjustments may not be a factor. CL’s pattern of an early post-meal glucose drop followed by a delayed glucose rise suggests a mismatch between insulin activity and nutrient absorption rather than simply excessive basal insulin.
Answer C is correct. 75.86% of respondents chose this: “Delayed gastric emptying resulting in a mismatch between insulin action and glucose absorption. Consider a referral for a gastric emptying study.” Great job! This is the correct answer. Based on the information we have, CL’s long duration of type 1 diabetes increases the risk for autonomic neuropathy, which can affect gastric motility. The pattern of early post-meal hypoglycemia followed by delayed hyperglycemia 3–5 hours later is characteristic of delayed carbohydrate absorption. New symptoms of bloating and nausea further support the consideration of gastroparesis. Referral for evaluation and possible gastric emptying testing may be appropriate.
Finally, Answer D is incorrect. 13.30% chose this answer, “A high-carbohydrate and high-fat dietary pattern causing prolonged glucose elevations after meals.” This is not the best answer. While it is possible that meals high in carbohydrate and fat can delay gastric emptying and contribute to prolonged post-meal glucose elevations, the early glucose drop followed by a delayed rise, combined with new gastrointestinal symptoms and long-standing type 1 diabetes, makes delayed gastric emptying a more likely primary contributor.
We hope you appreciate this week’s rationale! Thank you so much for taking the time to answer our Question of the Week and participate in this fun learning activity!
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