The Food and Drug Administration (FDA) just approved another GLP-1 RA for use in children ages 10-17 with diabetes.

The injectable extended-release exenatide (Bydureon) is now the second glucagonlike peptide-1 receptor agonist (GLP-1 RA) approved for use in pediatric type 2 diabetes and the first with once-weekly administration. Liraglutide (Victoza) a daily injectable GLP-1 RA received approval for pediatric use in 2019 and metformin an oral biguanide has long been FDA approved for use children ten and older with type 2 diabetes.

During the annual scientific sessions of the American Diabetes Association, speakers expressed alarm about the rise in youth developing type 2 diabetes, noting that the condition typically progresses more rapidly and is less likely to respond well to metformin, compared with adults.

The approval was based on a 24-week, double-blind, placebo-controlled study in 82 children with type 2 diabetes aged 10 and older. They were randomized to 2 mg once-weekly exenatide extended release or placebo. At week 24, hemoglobin A1c in those randomized to the drug had dropped by 0.25 percentage points, compared with a 0.45 percentage point increase in the placebo group.

Based on the ADA Standards of Care for treating pediatrics with diabetes, the first treatment includes weight loss and exercise plus first line medications metformin and insulin if A1c is 8.5% or greater.

Furthermore, the initiation of any GLP-1 RA is only recommended once pancreatic antibodies are determined to be absent and if A1c goals have not met despite the initiation of metformin or insulin (see ADA standards algorithm below stating consider adding liraglutide (GLP-1 RA))

We have updated the electronic version of our Injectable PocketCard to reflect this update.

Download our Medication PocketCards today on our Website PocketCards , or CDCES Coach App (free).

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• Presentations by our team of experts
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2021 Diabetes Educator Course Flyer & Schedule (subject to change)

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Team of Experts: Our team of expert faculty has been fine-tuning this course for over fifteen years and we know what you need to succeed! In addition to informative lectures, we also use group activities and case studies to highlight the essential knowledge, skills, and strategies needed to succeed in diabetes education today!

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