A new aqueous glucagon analog formulation has been FDA approved and should be available in pharmacies later this year.
Dasiglucagon (Zegalogue) is an effective, reliable treatment to increase glucose levels following insulin-induced hypoglycemia in children and adolescents with type 1 diabetes. This conclusion is based on a double-blind study recently published in Diabetes Care, April 2021.
This ready-to-use, next-generation formulation is approved for ages 6 or older. Subcutaneous injection sites include the abdomen, buttocks, thighs, and upper arms. This prefilled syringe contains a stable liquid glucagon analog and can be stored for one year at room temperature.
The investigators report that dasiglucsagon treatment was well tolerated, with the usual adverse effects (nausea and vomiting) expected from glucagon treatment.
The dose of dasiglucagon is 0.6 mg to treat severe hypoglycemia in pediatrics over the age of 6 years and adults with diabetes. Download our Glucagon PocketCard to post and share with colleagues and people living with diabetes.
As with all glucagon injections, dasiglucagon can cause nausea and vomiting. After the dose is administered, roll the person on the side and seek medical help. When awake, give oral carbohydrates ASAP when safe to swallow, and consult package insert for detailed guidelines!
Preventing Future Episodes of Hypoglycemia
Most importantly, encourage people experiencing a severe low blood sugar to determine the cause of the hypoglycemic event and implement strategies to prevent future lows. Our free Glucagon Card is the perfect teaching tool to help reinforce prevention and early action!
Thank you for helping get the word out about these rescue medications for severe hypoglycemia. This hormone injection saves lives and is a must-have for anyone living with type 1 diabetes or those with type 2 on intensive insulin therapy.
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