Question of the Week | Best advice on adding new med, Mounjaro

The FDA recently approved the new ‘twincretin” dual incretin hormone therapy called Tirzepatide (Mounjaro).  The provider wants to start a person with type 2 diabetes on this new medication and asks for your consultation.  The person’s current medications for type 2 diabetes include metformin, empagliflozin (Jardiance), semaglutide (Ozempic), and Pravachol.  What is the best response to the provider?

  1. Inform provider that Tirzepatide (Mounjaro) is contraindicated in people taking SGLT-2 Inhibitors.
  2. Recommend stopping the semaglutide (Ozempic) before starting the Tirzepatide (Mounjaro).
  3. Reinforce the importance of prescribing a CGM before starting Tirzepatide (Mounjaro).
  4. Request provider also prescribes Glucagon rescue med in case of severe hypoglycemia.

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New Dual Incretin Injectable – “TwinCretin”

The FDA just approved a novel, dual incretin hormone therapy called Tirzepatide (Mounjaro).

This new twin incretin injectable includes not only a GLP-1 Receptor Agonist, but also a Glucose-dependent insulinotropic polypeptide (GIP), which magnifies the therapeutic effectiveness. The SURPASS studies indicate that study participants experienced an A1C drop of up to 2.5% and weight loss of up to 10kg or more.


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