Question of the Week | Which precaution when starting tirzepitide according to 2025 ADA Standards?
TZ is a 32-year-old female with type 2 diabetes and an A1C of 8.3% who takes metformin 1000mg twice daily and is on oral contraception. TZ is going to start tirzepitide 2.5mg weekly to help with weight loss and blood glucose management. According to the 2025 ADA Standards, what precaution would we recommend to TZ along with the initiation of tirzepitide?
According to the 2025 ADA Standards, what precaution would we recommend to TZ along with the initiation of tirzepitide?
- Reduce the metformin by 50% to prevent side effects and maintain B12 levels.
- Assess TZ’s risk of acidosis before initiating dual therapies.
- Provide a glucagon emergency kit in case of severe hypoglycemia.
- Suggest using a second form of contraception for at least 4 weeks.
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